33332-25-1, The chemical industry reduces the impact on the environment during synthesis 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
Example 24 5-{[3-(Cyclopropylmethyl)-2,3,4,5-tetrahydro-1 H-3-benzazepin-7-yl]oxy)-N-methyl-2- pyrazinecarboxamide (E24) Step 1: 1,1-Dimethylethyl 7-({5-[(methyloxy)carbonyl]-2-pyrazinyl}oxy)-1,2,4,5- tetrahydro-3H-3-benzazepine-3-carboxylate; 1,1-Dimethylethyl 7-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (Description 3 of WO 02/40471) (40 g, 0.15 mole) was dissolved in dry dimethylformamide (200 ml) and treated with sodium hydride (60% in mineral oil, 6.4 g, 0.16 mole). The mixture was stirred at room temperature for 1 hour and then cooled in ice. Methyl 5-chloro- 2-pyrazinecarboxylate (31.2 g, 0.18 mole) was added and the mixture stirred at room temperature for 18 hours. The mixture was poured into ice/water and the resulting solid collected by filtration. This was dissolved in ethyl acetate, dried (sodium sulphate) and evaporated under reduced pressure. The residue was purified by column chromatography eluting with ethyl acetate/pentane (1:2) to afford the title compound ?H NMR (CDCl3) No. 8.84 (H, s), 8.48 (H, s), 7.18 (H, m), 6.94 (2H, m), 4.01 (3H, s), 3.58 (4H, m), 2.92 (4H, m), 1.49 (9H, s)..
The chemical industry reduces the impact on the environment during synthesis Methyl 5-chloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem