A common compound: 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 23688-89-3
General procedure: The compounds were prepared following a literature procedure.57 To a solution of carboxylic acid (1.0 equiv.) in anhydrous CH2Cl2(0.1 M) was added oxalyl chloride (1.5 equiv.) and DMF (0.1 equiv.) at0 C, and the resulting mixture was allowed to warm to RT for 2 h. Thenthe volatiles were concentrated under reduced pressure, and the residuewas dissolved in anhydrous CH2Cl2 (0.1 M), followed by the addition ofaniline (1.0 equiv.) and triethylamine (1.1 equiv.), and the resultingmixture was stirred at RT for another 2 h. After completion monitoredby TLC, the reaction mixture was quenched with H2O and extractedwith CH2Cl2 (3¡Á20 mL), and washed with 1% HCl solution, and thensat. Na2CO3 (aq.). The combined organic layers were dried over MgSO4and concentrated in vacuo.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 23688-89-3, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zhou, Qingqing; Reekie, Tristan A.; Abbassi, Ramzi H.; Indurthi Venkata, Dinesh; Font, Josep S.; Ryan, Renae M.; Munoz, Lenka; Kassiou, Michael; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5852 – 5869;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem