Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., 5049-61-6
To a stirred solution of pyrazin-2-amine (2.00 g, 21 .0 mmol) in CHCI3 (25 mL) was added NCS (3.65 g, 27.3 mmol) portionwise and the reaction mixture was stirred at room temperature for 6h. Progress of reaction was monitored by TLC. After completion, the reaction mixture was poured in to ice cold H20 (20 mL) and extracted with EtOAc (2 c 40 mL). The organic layer was separated, washed with brine (25 mL), dried over anhydrous Na2S04 and concentrated under vacuum. The crude obtained was purified by combi flash chromatography (20% EtOAc in hexane) to afford 3,5-dichloropyrazin-2-amine X-10a (1 .50 g) as an off-white solid. Yield: 37%. (0851) 1H NMR (400 MHz, DMSO-cfe) d 7.02 (brs, 2H), 8.06 (s, 1 H).
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Reference:
Patent; UCB PHARMA GMBH; PEGURIER, Cecile; PROVINS, Laurent; CARDENAS, Alvaro; LEDECQ, Marie; MUELLER, Christa E.; HOCKEMEYER, Joerg; EL-TAYEB, Ali; BOSHTA, Nader; RASHED, Mahmoud; (165 pag.)WO2019/243303; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem