In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 36070-80-1
Preparation of Starting Material 5-chloro-N,N-dimethylpyrazine-2-carboxamide (SM-1) 5-chloropyrazine-2-carboxylic acid (1.00 gram, 6.31 mmol) in dichloromethane (30 ml) was treated with catalytic amount of dimethylformamide, followed by (COCl)2 (0.85 ml, 9.46 mmol). The resulting mixture was stirred over night. The reaction was concentrated in vacuo, and dried under vacuum to give desired 5-chloropyrazine-2-carbonyl chloride as solid (1.05 g, 100%).
The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc; US2010/234285; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem