5049-61-6, A common compound: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Example 1 1-(5-{[3-(Cyclopropylmethyl)-2,3,4,5-tetrahydro-1 H-3-benzazepin- 7 -yl]oxy}-2- pyrazinyl)-2-pyrrolidinone (E1) Step 1: 5-Chloro-2-pyrazinamine; Aminopyrazine (10g, 10.5mmole) was dissolved in dry dimethylformamide (60ml) and was treated with N-chlorosuccinimide (15.36g, 11.5mmole) under argon at 0C. The mixture was stirred for 30 minutes and then allowed to warm to room temperature. The mixture was poured onto water and extracted with diethyl ether (x 5). The diethyl ether layers were combined and evaporated in vacuo. The resulting residue was purified by column chromatography (1: 9 ethyl acetate: pentane) to afford the title compound (1.40g). ?H NMR (CDCI3) 8.02 (1H, s), 7.76 (1H, s), 4.61 (2H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/97778; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem