Adding some certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6. 5049-61-6
C1: According to the standard of adding 1 g of 2-cyanopyrazine to 20 ml of solvent, 100 ml of a sodium hypochlorite solution and 100 ml of a mixed solution of sodium hydroxide and potassium hydroxide are sequentially added to 10 g of 2-cyanopyrazine.The pH of the mixed solution of sodium hydroxide and potassium hydroxide is 8,Then stirring at 40 C for 2 hours, followed by hydrolysis, rearrangement to obtain 2-aminopyrazine; C2: the 2-aminopyrazine obtained in the step C1 is added to the bromine to carry out a bromination reaction for 0.5 hour to obtain 2-amino-3,5-dibromopyrazine; C3 The 2-amino-3,5-dibromopyrazine obtained in the step C2 is subjected to a substitution reaction with morpholine at 40 C for 0.5 hour in a molar ratio of 1:1 to obtain 2-amino-5-bromo-3- Morpholinylpyrazine solution; C4: 2-amino-5-bromo-3-morpholinylpyrazine was dissolved and distilled to remove an organic solvent, followed by washing with water for 2 hours to obtain crude 2-amino-5-bromo-3-morpholinylpyrazine; C5: The crude 2-amino-5-bromo-3-morpholinylpyrazine was repeatedly subjected to rectification three times to obtain a finished product.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Pyrazin-2-amine.
Reference:
Patent; Zaozhuang Jiu Xing Biological Technology Co., Ltd.; Sun Yan; (5 pag.)CN108570011; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem