As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 486460-21-3 name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 486460-21-3
The resulting product is dissolved in tetrahydrofuran (200 ml) and the solution is added in about 90 minutes to a solution obtained dissolving chloroacetyl chloride (28.6 g, 253 mmol) in tetrahydrofuran (200 ml), under N2 atmosphere and under stirring. The solution is left under stirring at 25C for 1 h. After completion of the reaction, a 25% NaOH solution (80 g) is added, the phases are separated and the aqueous phase is extracted with 2×100 ml of tetrahydrofuran. The solvent is concentrated under reduced pressure to obtain 160 g of a crude, which is added with methyl-tert-butyl ether (220 ml) and the solution is heated under reflux of the solvent mixture. The solution is cooled to 10C under strong stirring for 3h. The product (56.1 g, 209 mmol, 89% yield) is a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Dipharma Francis S.r.l.; EP2270009; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem