In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-chloropyrazine, other downstream synthetic routes, hurry up and to see.
Adding a certain compound to certain chemical reactions, such as: 33332-29-5, name is 2-Amino-5-chloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-29-5, 33332-29-5
4-(6-chloroimidazo[l,2-a]pyrazin-2-yl)-N,N-dimethylbenzenamine (L21).; In a double necked round bottomed flask equipped with condenser and under nitrogen flow were introduced 5-chloro-2-amino-pyrazine (61 mg, 0.47 mmol), 2-bromo-4′-dimethylamino- acetophenone (170 mg, 0.71 mmol) and anhydrous acetonitrile (7 mL). The reaction mixture was refluxed for 3 hrs. After it cooled down, NaHCO3 (71 mg, 0.85 mmol) was added. The reaction was refluxed for another 6 hrs. The solvent was removed and the crude product (221 mg) was purified by FCC (hex/DCM/AcOEt = 2:2:1), to afford 9 mg (yield 7%) of the product as yellow solid. 1H NMR (270 MHz; CDCl3), delta 8.82 (s, IH, Ar-H), 8.09 (s, IH, Ar- H), 7.822 (s, IH, Ar-H), 7.818 (d, 3JHH = 8.9 Hz, 2H, Ar-H), 6.77 (d, 3JHH = 8.7 Hz, 2H, Ar- H), 3.02 (s, 6H, NCH3). m/z (CI-MS): 273 ([M+l] +), 261, 239 ([M-Cl +I] +).; Imidazopyrazine L21 was synthesized from condensation of chloropyrazine P13 and bromoacetophenone Bl (eq 9). The amine 67 was very unreactive though it is very soluble in acetonitrile. Long reaction time and stronger bases such as triethylamine were examined with limited success
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES, as represented by the secretary of HEALTH AND HUMAN SERVICES; WO2007/124345; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem