In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486460-21-3 as follows. 486460-21-3
The compound of formula 7 (1.3 g, 0.01 mol) was reacted withCompound 9 (1.9 g, 0.01 mol) was added to a 50 ml two-necked flask,Join20 ml of methylene chloride,Added HOBt at -10-10 (1.49,0.011mol) andEDC.HCl (2.9 g, 0.015 mol) The reaction mixture was stirred at room temperature for 8 hours,After completion of the reaction, 15 mL of aqueous NaHCO3 solution was added and the organic phase was saturatedWashed with brine, dried over anhydrous sodium sulfate, concentrated, purified by column chromatography,To give 2.67 g of the compound of formula b,The yield was 89.1%.
According to the analysis of related databases, 486460-21-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.; Zhu Guoliang; He Qian; Qian Lingfeng; Xu Yingzhou; Yan Pucha; (13 pag.)CN106146514; (2016); A;,
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