6705-33-5, A common compound: 6705-33-5, name is Pyrazin-2-ylmethanol, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Step 2 – 2-(Bromomethyl)pyrazine (0524) [00341] To a solution of pyrazin-2-ylmethanol (750 mg, 6.81 mmol) in dichloromethane (10 mL) was added phosphorus tribromide (2.77 g, 10.2 mmol) dropwise and the reaction mixture was stirred at 15 C for 16 hrs. On completion, methanol (20 mL) was added to the reaction mixture. Then the mixture was concentrated in vacuo and the resulting solid was purified by silica gel chromatography (dichloromethane:methanol = 50:1) to give the title compound. 1H NMR (300MHz, CD3OD) delta = 8.86 (s, 1H), 8.74 (br. s., 1H), 8.63 (d, J = 2.6 Hz, 1H), 4.72 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-ylmethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel P.; SAIAH, Eddine; (264 pag.)WO2017/156181; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem