Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 132426-19-8, name is 2-Bromo-1-(pyrazin-2-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., 132426-19-8
To a solution of 1-(pyrazin-2-yl)ethan-1-one (250 mg, 2.03 mmol) in AcOH (5 mL), pyridinium bromide perbromide(780 mg, 2.4 mmol) was added and allowed the mixture to stir at room temperature for 48hours. After TLC showed completion, diluted the mixture with EtOAc (20 mL) and washedwith water (3 x 10 mL). The organic layer was dried over Na2SO4 and concentrated to obtaincrude 2-bromo-1-(pyrazin-2-yl)ethan-1-one, which was used in next step without further purification(300 mg, crude). To a solution of 1-(2,6-dimethylphenyl)thiourea (134 mg, 0.7 mmol)in DMF (5 mL), crude 2-bromo-1-(pyrazin-2-yl)ethan-1-one (300 mg, 0.7 mmol) and triethylamine(0.31 mL, 2.2 mmol) were added successively and heated the mixture at 70C for 2hours. After TLC showed completion, reaction mixture was diluted with EtOAc (20 mL) andwashed with water (3 x 10 mL). The organic layer was dried over Na2SO4 and concentrated.The resulting residue was purified by column chromatography (silicagel, 100-200) and thedesired product was eluted with 20% EtOAc in hexane. Concentration of the pure fractionsafforded 52 (135 mg, 32% yield), as a pale yellow solid; 1H NMR: (400 MHz, DMSO-d6): delta 2.23(s, 6H), 7.14-7.20 (m, 3H), 7.45 (s, 1H), 8.54 (d, J = 2.4 Hz, 1H), 8.61 (t, J = 1.6 Hz, 1H), 8.99 (d, J = 1.6 Hz, 1H), 9.43 (1H, s); 13C NMR: (300 MHz, CDCl3) delta 18.1, 107.7, 128.1, 128.9, 137.0,137.4, 142.5, 142.7, 143.8, 148.3, 148.8, 171.0; LCMS m/z (M+H) 283.08, purity 99.8%; HRMSMS ESI m/z calcd for C15H14N4S (M+H)+ 283.1012, found 283.1001 (Delta 1.1 ppm).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Kesicki, Edward A.; Bailey, Mai A.; Ovechkina, Yulia; Early, Julie V.; Alling, Torey; Bowman, Julie; Zuniga, Edison S.; Dalai, Suryakanta; Kumar, Naresh; Masquelin, Thierry; Hipskind, Philip A.; Odingo, Joshua O.; Parish, Tanya; PLoS ONE; vol. 11; 5; (2016);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem