Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., 1458-18-0
Under an argon atmosphere,Isoamyl nitrite (26.6 mL, 200 mmol) was added to a THF solution of methyl 3-amino-5,6-dichloropyrazine-2-carboxylate (4.44 g, 20.0 mmol) in THF (30 mL). The reaction mixture was stirred at 80 C. for 17 hours. After standing to cool, the low boiling point compound was distilled off to obtain a crude product. This crude product was purified by silica gel column chromatography (developing solvent: hexane / ethyl acetate = 100/0 to 90/10) to obtain methyl 5,6-dichloropyrazine-2-carboxylate (2.29 g, 55% ) As a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; SHONO, TOMOHIRO; (23 pag.)JP2015/140319; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem