In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120984-76-1, name is 2-Bromo-3-methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 120984-76-1
A solution of C39 (2.35 g, 5.78 mmol), 2-bromo-3-methylpyrazine (1.0 g, 5.8mmol), [1 ,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (634 mg, 0.866mmol), and potassium carbonate (3.2 g, 23 mmol) in a mixture of 1,4-dioxane (30 mL) and water (8 mL) was stirred at 100 C for 2 hours. The reaction mixture was then filtered and concentrated in vacuo. The residue was purified via silica gel chromatography (Eluent: ethyl acetate) to afford the product as a yellow solid. Yield:0.90 g, 2.4 mmol, 42%. 1H NMR (400 MHz, CDCI3) oe 8.46(brd, J=2 Hz, 1H), 8.41 (d, J=2.6 Hz, 1H), 7.15 (d, J=8.2 Hz, 1H), 6.60 (dd, J=8.3, 2.3 Hz, 1H), 6.54 (d, J=2.3 Hz, 1H), 3.76 (5, 3H), 2.43 (5, 3H), 1.24-1.37 (m, 3H), 1.08-1.18 (m, 18H).
The synthetic route of 120984-76-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; ZHANG, Lei; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/162515; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem