In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5521-58-4, name is 5-Methylpyrazin-2-amine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 5521-58-4
l-Chloro-N,N,2-trimethyl-l-propenylamine (2.67 mL, 20 mmol) was added to a solution of 3-{[6-(azetidin-l-ylcarbonyl)pyridin-3-yl]oxy}-5-[(phenylmethyl)oxy]benzoic acid (6.18 g, 15.3 mmol) in DCM (100 mL) and the reaction stirred at RT for 50mins. 2-Amino-5- methylpyrazine (3.34 g, 30.6 mmol) and pyridine (2.5 mL, 30.6 mmol) were added and the reaction stirred overnight. The solvent was removed in vacuo, and the residue taken up in ethyl acetate(350 mL). The organic phase was washed with water (2 x 100 mL), brine (100 mL), dried (MgSO4), filtered, and evaporated in vacuo. The residue was chromatographed on silica, eluting with a gradient of 50-75% ethyl acetate in isohexane, to give the desired material (4.01 g). 1H NuMR delta (CDCl3): 2.28 (quin, 2H), 2.49 (s, 3H), 4.18 (t, 2H), 4.63 (t, 2H), 5.05 (s, 2H), 6.78 (s, IH), 7.10 (s, IH), 7.25 – 7.37 (m, 7H), 8.04 (d, IH), 8.07 (s, IH), 8.25 (s, 2H), 9.46 (s, IH); m/z 496 (M+H)+
The synthetic route of 5521-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/7041; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem