Some common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, molecular formula is C4H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 24241-18-7
A 500ml three-neck flask, was added morpholine (9.6g, 0.11mol) and 2-amino-3,5-dibromo-pyrazine (25.3g, 0.1mol) and N- methylpyrrolidinone (100ml), and at 80 reaction 6h, TLC tracking, cooled to room temperature, add water 400ml, stirring, suction filtered and dried to give a yellow solid 22.5g, a yield of 86.7%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24241-18-7, its application will become more common.
Reference:
Patent; Hubei University of Technology; Liu, Mingxing; Jiang, Weidong; Wang, Wanxia; (6 pag.)CN105622526; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem