36070-80-1, Adding a certain compound to certain chemical reactions, such as: 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-80-1.
Step 1: 5-chloro-N-[(lS)-2,2,2-trifluoro-l-methylethyl]pyrazine-2-carboxamideN,N-Diisopropylethylamine (1.3 mL, 7.5 mmol) was added to a mixture of 5- chloropyrazine-2-carboxylic acid (0.40 g, 2.5 mmol), N,N,N’,N’-tetramethyl-0-(7- azabenzotriazol-l-yl)uronium hexafluorophosphate (1.0 g, 2.8 mmol) and (2S)-1,1,1- trifluoropropan-2-amine (0.28 g, 2.5 mmol) (Oakwood: Cat.No.44272) in methylene chloride (10 mL). The reaction mixture was stirred at room temperatureovernight. The reaction mixture was worked up with saturated aqueous NaHCC , and extracted with ethyl acetate (3x 20 mL). The combined organic layers were washed with brine, dried over MgS04, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-15%) to afford the desired product (0.64 g, 73%). LCMS (M+H) +: m/z = 253.9/255.9.
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Reference:
Patent; INCYTE CORPORATION; YAO, Wenqing; BURNS, David M.; ZHUO, Jincong; WO2012/177606; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem