In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3149-28-8, name is 2-Methoxypyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 3149-28-8
1.9 g (0.017 mol) of 30 % hydrogen peroxide are added to a solution of 1.1 g (0.01 mol) of 2-methoxy-pyrazine in 3 ml of glacial acetic acid and the resulting solution is heated at 65-68C for 17 hours. The solution is concentrated to 1/3 of the original volume, diluted with the same amount of water and concentrated again. The residue is extracted with chloroform and the combined organic phases are washed with saturated sodium chloride solution and dried over sodium sulfate. After concentration, two amounts, each of 25 ml, of toluene are added to the residue obtained and are concentrated again. The desired title compound, which can be used directly for further reactions, is obtained in a yield of 0.98 g (77 % of theory). ‘H NMR (300 MHz, CDCI3) : 7.988 ppm (d (J=4.2 Hz), 1 H) ; 7.766-7. 773 ppm (m, 1 H) ; 7.745 ppm (dxd (J=4.2 and 1.5 Hz), 1 H) ; 3.995 ppm (s, 3H).
The synthetic route of 3149-28-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2003/87067; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem