In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 4858-85-9
To a solution of l-(quinolin-2-yl)piperidin-4-ol (see PREPARATION Pl . l ; 2.0 g, 8.7 mmol) in DMF (30 mL) at room temperature was added sodium hydride (60% wt in mineral oil) (0.47 g, 17.4 mmol) at 0 C. The mixture was stirred at room temperature for 60 min and then 2, 3-dichloro-pyrazine (1.2 g, 8.7 mmol) was added. The reaction mixture was heated to 90 C overnight and then diluted with water (60 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were washed with water (40 mL) and brine (40 mL), dried over Na2S04, and filtered. The filtrate was evaporated in vacuo and the residue was purified by flash column chromatography on silica gel (10% to 30% EtOAc in petroleum ether) to give the title product ( 2.0 g, 5.8 mmol, 70% yield ) as white solid. ESI-MS (M+l): 341 calc. for
The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer; HORNE, Daniel B.; HU, Essa; KALLER, Matthew R.; MONENSCHEIN, Holger; NGUYEN, Thomas T.; REICHELT, Andreas; RZASA, Robert M.; WO2011/143495; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem