27398-39-6, Name is 3-Chloropyrazine-2-carboxylic acid, 27398-39-6, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Step 4: 3-chloro-N-[[1 -r3-chloro-5-r2-(trifluoromethyl)cvclopropyll-2-Pyridyllcvclopropyllmethyllpyrazine-2-carboxamide (compound A.1 1 1 )147 mg [1 -[3-chloro-5-[2-(trifluoromethyl)cyclopropyl]-2-pyridyl]cyclopropyl]methanamine (step 3) was dissolved in 3 ml of dichloromethane and 0.142 ml triethylamine was added. After cooling to 0¡ãC, 193 mg 3-(ethyliminomethyleneamino)-N,N-dimethyl-propan-1-amine hydrochloride, 84 mg 3-chloropyrazine-2-carboxylic acid and 141 mg 1- hydroxybenzotriazole were added. The mixture was stirred overnight at ambient temperature. Then water was added. The layers were separated, the organic layer was dried over anhydrous sodium sulphate, filtered and concentrated. Crude material was obtained as an orange oil, which was purified by flash chromatography on silica gel with heptane/ethyl acetate as a solvent. Thus, 161 mg of 3-chloro-N-[[1-[3-chloro-5-[2- (trifluoromethyl)cyclopropyl]-2-pyridyl]cyclopropyl]methyl]pyrazine-2-carboxamide was obtained as a yellow sticky solid. 1H-NMR (CDCI3): 8.42 ppm (d, 1 H), 8.38 ppm (d, 1 H), 8.18 ppm (s, 1 H), 7.78 ppm (s, 1 H, broad), 7.31 ppm (s, 1 H), 3.66 ppm (d, 1 H), 2.26 ppm (m, 1 H), 1 .78 ppm (m, 1 H), 1.57 ppm (m, 1 H), 1.39 ppm (m, 1 H), 1.18 ppm (m, 4H).
Statistics shows that 3-Chloropyrazine-2-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 27398-39-6.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; PITTERNA, Thomas; LOISELEUR, Olivier; WORTHINGTON, Paul, Anthony; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; BOBOSIK, Vladimir; WO2013/64521; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem