Some tips on 5-Bromo-3-methoxypyrazin-2-amine

According to the analysis of related databases, 5-Bromo-3-methoxypyrazin-2-amine, the application of this compound in the production field has become more and more popular.

5900-13-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5900-13-0 as follows.

5-bromo-3-methoxy-2-pyrazinamme (13.5g), hexane-2,5-dione (9g) and para- toluenesulphonic acid hydrate (0.5g) in toluene (200ml) was heated under reflux using a Dean and Stark trap to collect the water. After 16h, the solution was allowed to cool, EPO concentrated to 50ml and passed through a pad of silica gel eluting with dichloromethane to collect the subtitle compound. Yield 17g.1H NMR (D6-DMSO):8.25 (IH, s), 5.92 (2H, s), 4.02 (3H, s), 2.02 (6H, s)

According to the analysis of related databases, 5-Bromo-3-methoxypyrazin-2-amine, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2007/35154; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem