Some common heterocyclic compound, 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, molecular formula is C16H11ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 41270-66-0
Under the protection of nitrogen,Add 3-methyl-2-chloro-quinoxaline (532 mg, 2.00 mmol) to cis-5-(isopropylaminomethyl)tetrahydrofuran-2-yl)methanol (1.04 g, 6.00 mmol)N-methylpyrrolidone(50mL) solution,The reaction was heated to 190 C for 15 h, and the reaction was monitored by LC-MS.The reaction was cooled, and ice water was added to the mixture, and ethyl acetate (50mL*3)The organic mixed phase was washed with water (50 mL) and saturated brine (50 mL*2).Filtration, solvent removal under reduced pressure, purification by chromatography on silica gel column, and collected under reduced pressure.Drying in vacuo gave 641.5 mg of Compound VIII as a white solid.Yield: 79.6%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41270-66-0, its application will become more common.
Reference:
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zeng Yanqun; Yan Shengyong; Zhang Tao; Wang Ying; (17 pag.)CN108623541; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem