41270-66-0, Name is 5-Chloro-2,3-diphenylpyrazine, 41270-66-0, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
2-[4-(tert-butoxycarbonyl)(isopropyl)aminobutoxy]-N-(methylsulfonyl)acetamide (20.0 g, 0.055 mol)And dissolved in methanol (110 mL),Trifluoroacetic acid (6.8 g, 0.06 mol) was added and the reaction stirred at 65 C for 6 hours until the reaction was complete. The reaction mixture was added dropwise to stirred water (200 mL), cooled to 0 C for 3 hours and filtered to give the intermediate compound 2- [4- (isopropyl) aminobutoxy] -N- (methylsulfonyl) acetamide) and then dissolved in methanol (40 mL)5-Chloro-2,3-diphenylpyrazine (16.0 g, 0.06 mol)N, N-diisopropylethylamine (15.5 g, 0.12 mol),The reaction mixture was stirred for 8 hours at 100 C. The reaction mixture was allowed to cool to room temperature. Water (40 mL) was added and the mixture was cooled to -10 C for 3 hours. The resulting mixture was filtered to give a solution of celecoxib (25.0 g) , The reaction of this step is as follows
Statistics shows that 5-Chloro-2,3-diphenylpyrazine is playing an increasingly important role. we look forward to future research findings about 41270-66-0.
Reference:
Patent; Hunan Ouya Biological Co., Ltd.; Li Xingmin; (10 pag.)CN105949135; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem