Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., 5049-61-6
Pyrazin-2-amine (11.3 g, 118.9 mmol) was dissolved in acetonitrile (100 mL) and Nchlorosuccinimide(NCS, 15.8 g, 118.9 mmol.) was added slowly inportions. Then, the reaction mixture was heated up to 40 and stirreduntil the amount of the main product did not increase anymore. Thesolution was filtered through Celite and the filter cake was washed byEA. The combined filtrate was washed by saturated aqueous NaHCO3solution (30 mL¡Á3) and brine, dried over anhydrous Na2SO4 anddecolorized by active charcoal. The mixture was filtered andconcentrated in vacuo. The precipitate was collected by filtration, andthe filtrate was purified on silica gel. A total of 8.4 g (yield 55%) wasobtained for compound 11b. 1H NMR (400 MHz, CDCl3): delta 8.01 (d, 1H,J=1.4 Hz), 7.76 (d, 1H, J=1.4 Hz), 4.57 (s, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Guo, Shuang; Xu, Mingshuo; Guo, Qi; Zhu, Fuqiang; Jiang, Xiangrui; Xie, Yuanchao; Shen, Jingshan; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 748 – 759;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem