486460-21-3, A common heterocyclic compound, 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H7F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 26 2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-l,2,4-triazol-3- yl)thio)-l-(3-(trifluoromethyl)-5,6-dihydro-[l,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl)ethanone 2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-4-(4-fluorophenyl)-4H-l,2,4-triazol-3- yl)thio)acetic acid and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[l ,2,4]triazolo[4,3- a]pyrazine was dissolved in DMF and then cooled to 0 C followed by addition of HBTU and DIPEA, reaction was monitored by TLC and then reaction was quenched by water and compound was extracted by ethyl acetate. Product was purified by column chromatography. NMR (DMSO-ck, 400 MHz): 7.10-7.03 (m, 2H), 6.77-6.70 (m, 3H), 6.40 (d, J = 5.6 Hz, 2H), 5.03 (s, 1H), 4.84 (s, 1H), 4.24-4.19 (m, 4H), 4.05-4.00 (m, 2H), 3.72 (s, 3H), 3.60 (s, 3H), 1.53 (s, 6H). m/z Relative intensities: 606.1 (M+)100 %.
The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CADILA HEALTHCARE LIMITED; AGARWAL, Sameer; DESAI, Ranjit, C.; WO2013/164838; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem