A common heterocyclic compound, 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 23611-75-8.
Add methyl 6-chloropyrazine-2-carboxylate (20. 0 g, 116 mmol) in THF (1 00 mL) to methylmagnesium bromide (3.0 mol/L) in diethyl ether (120 g, 348 mmol, 3.0 mol/L) at 0 C and the mixture is stirred at this temperature for 2 h. The reaction is quenched with 1.0HCl solution (100 mL) and extracted with EtOAc (100 mL x 3). The combined organic layers are washed with brine (100 mL), dried over anhydrous sodium sulfate, concentrated to afford a yellow oil. The yellow oil is purified by column chromatography on silica gel eluting with 0-30% EA in PE to afford title compound (3.80 g, 18.0%) as brown oil. LCMS (m/z): 5 172.8 [M+H]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 6-chloropyrazine-2-carboxylate, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; MA, Tianwei; WU, Liang; ZHANG, Xuejun; (109 pag.)WO2019/41340; (2019); A1;,
Pyrazine – Wikipedia,
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