A common compound: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5049-61-6
A novel process for the reaction of a secondary amine by reaction of 2-aminopyrazine with triethylamine, comprising the steps of:Under nitrogen protection,Under nitrogen protection,2-aminopyrazine (95 mg, 1 mmol) was added to a 50 mL Schlenk tube,Triethylamine (304 mg, 3 mmol),[(Bt) 2 * Ir * P (nBu) 3] OTf (9.6 mg, 0.01 mmol, 1.0 mol%),Add 2.0mL xylene;The reaction solution was reacted at 155 C for 10 h,The resulting solution was separated on a silica gel column from 200 to 300 mesh (eluent 1:10 ethyl acetate / petroleum ether)After removal of the solvent,To get the product.Yield: 78%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5049-61-6, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jingnan University; Zhang, Songlin; Fan, Huijun; Zhang, Donghui; Wang, Dawei; Ding, Yuqiang; (6 pag.)CN104710257; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem