6705-33-5, Adding some certain compound to certain chemical reactions, such as: 6705-33-5, name is Pyrazin-2-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6705-33-5.
Example 1018; Step A; To a suspension of triphenylphosphine polystyrene (3 gm, 1 mmol/gm) in dry dichloromethane (20 ml) was slowly added bromine (154 muL). The resulting mixture was stirred at room temperature for 10 min, a solution of commercially available pyrazin-2-yl-methanol (114 mg) in dry dichloromethane (10 ml) was added and stirring at room temperature was continued for 21? h. The mixture was filtered, concentrated under reduce pressure at 20 C. and purified by flash chromatography (silica, cyclohexane/ethyl acetate). The obtained material was dissolved in dry N,N-dimethylformamide (1.5 mL) and added to a suspension of the title compound from Example 1007c (22.3 mg) and potassium carbonate (69.1 mg) in dry N,N-dimethylformamide (1.5 mL). The resulting mixture was stirred at room temperature for 16 h and then concentrated under reduce pressure. The remaining residue was purified by flash chromatography (silica, dichloromethane/methanol) to afford the title compound (6.8 mg; 25%) as a single isomer. [MH]+=539.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6705-33-5.
Reference:
Patent; ALANTOS PHARMACEUTICALS, INC.; US2007/155739; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem