13301-04-7,Some common heterocyclic compound, 13301-04-7, name is Methyl 3,6-dibromopyrazine-2-carboxylate, molecular formula is C6H4Br2N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of LiOH (121 mg, 5.07 mmol) in water (1 mL) was slowly added to a solution the pyrazine ester (500 mg, 1.67 mmol) in 1:1 THF/water (8 mL) at 0 C. After stirring at 0 C. for 45 min. The solvent was removed under reduced pressure. The residue was dissolved in a mixture of DCM and 1N aq. HCl. The organic layer was separated and the aqueous extracted twice with DCM. The combined organic extracts were dried (Na2SO4), filtered and concentrated to afford 350 mg (74%) of a cream colored solid. MS m/z (ES): 282 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3,6-dibromopyrazine-2-carboxylate, its application will become more common.
Reference:
Patent; de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael; US2011/59118; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem