32111-21-0, name is 2-Iodopyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 32111-21-0
2- (5- [1, 3] Dioxolan-2-yl-2, 4-dimethoxy-phenyl)-4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolane (Ex-12B, 2.22 g, 6.60 mmol, containing borolane impurity) was dissolved in DME (60 mL) and 2-iodopyrazine (0.59 mL, 6.0 mmol) was added. 2M aqueous NA2CO3 (17.8 ML, 35.6 mmol) was added and the mixture was purged with nitrogen for 20 min. Tetrakis (triphenylphosphine) palladium (0) (0.69 g, 0.60 mmol) was added and the mixture was heated at reflux for 2.5 h. After cooling, water (50 mL) was added and the mixture was extracted with CH2CI2 (2X30 mL). The organic phase was washed with brine (1X20 ML), dried over sodium sulfate, filtered, and concentrated. Purification of the resulting yellow-orange solids via silica chromatography (50-80% EtOAc/hexanes) provided 1.02 g OF 2- (5- [1, 3] dioxolan-2- yl-2, 4-dimethoxy-phenyl)-pyrazine as a yellow solid (59% YIELD).’H-NMR (CDCIS) 8 9.10 (d, J = 2 Hz, IH), 8.61 (m, 1H), 8.39 (d, J = 3 Hz, I H), 8.07 (s, I H), 6.57 (s, IH), 6.14 (s, 1H), 4.13-4. 18 (m, 2H), 4.01-4. 05 (m, 2H), 3.95 (s, 3H), 3.93 (s, 3H).
Statistics shows that 32111-21-0 is playing an increasingly important role. we look forward to future research findings about 2-Iodopyrazine.
Reference:
Patent; ATHEROGENICS, INC.; WO2004/56727; (2004); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem