55557-52-3,Some common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A: 3-[(4-Methoxybenzyl)amino]pyrazine-2-carbonitrile To a solution of 3-chloropyrazine-2-carbonitrile (500 mg, 3.6 mmol) in dichloromethane (DCM) (4.0 mL) was added, 4-methoxy-benzenemethanamine (470 muL, 0.0036 mol), N,N-diisopropylethylamine (620 muL, 0.0036 mol) and the resulting mixture was stirred at room temperature (25 C.) for 5 h. The crude residue was purified by flash column chromatography to yield the desired product (650 mg, 75%). MF=C13H12N4O; LCMS calculated for C13H13N4O(M+H)+: m/z=241.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropyrazine-2-carbonitrile, its application will become more common.
Reference:
Patent; INCYTE CORPORATION; US2008/119491; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem