Some common heterocyclic compound, 5780-66-5, name is Pyrazine-2-carbaldehyde, molecular formula is C5H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5780-66-5
EXAMPLE 2; This example describes synthesis of another mid-transition metal complex of the invention, with ligand synthesis as illustrated in Scheme 3 and described in part (a), and metallation as illustrated in Scheme 4 and described in part (b). [00163] (a) The imine-containing ligand 3 may be synthesized by reaction of 2,6-pyrazine carboxaldehyde with 2,6-diisopropylanine as illustrated in Scheme 3: [C00023] [00164] A 250-mL flask is charged with 2,6-pyrazine carboxaldehyde and methanol. A slight excess of 2,6-diisopropylaniline (1.1 eq) is added by pipet. The mixture is stirred at room temperature in methanol for 1 d. The solvent and unreacted aniline are removed in vacuo to give the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5780-66-5, its application will become more common.
Reference:
Patent; SRI International; US6841676; (2005); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem