19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step F: To a solution of 3-(2,5-difluoro-4-(methylsulfonyl)phenoxy)-l,4′- bipiperidin-2-one HC1 salt (500 mg, 1.2 mmol) and DIEA (0.52 mL, 3.0 mmol) in DMF (6 mL) was added 2,5-dichloropyrazine (264 mg, 1.8 mmol). The reaction was heated at 120 ¡ãC overnight. The reaction was cooled to ambient temperature and partitioned between water and ethyl acetate. The organic layer was separated and the aqueous washed with EtOAc. The combined organic layers were dried with MgS04 and concentrated. The crude residue was purified by column chromatography to give (S)-l’-(5-chloropyrazin-2-yl)-3-(2,5-difluoro-4- (methylsulfonyl)phenylamino)-l,4′-bipiperidin-2-one(0.37g, 0.73 mmol, 62percent) Mass spectrum (apci) m/z = 500.2 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Dichloropyrazine, its application will become more common.
Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENCSIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald Jay; PRATT, Scott Alan; SINGH, Ajay; TURNER, Timothy M.; WO2011/146335; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem