As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 123-32-0 name is 2,5-Dimethylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 123-32-0
54 g (498 mmol) of 2,5-dimethylpyrazine (manufactured by Tokyo Chemical Industry Co., Ltd.) and 224 g (2.02 mol) of selenium dioxide were added to 840 ml of a mixed solution of pyridine and water (mixing mass ratio: 20/1) And the mixture was heated under reflux for 48 hours. The reaction solution was cooled to ambient temperature and filtered, and the filtration residue was washed with a mixed solution of pyridine and water (mixing mass ratio: 20/1), the filtrate and the washing solution were combined and the liquid was distilled off to obtain a solid It was.The resulting solid was dispersed in 2 M dimethylamine aqueous solution used as an extraction solvent, and residual solids were removed from the extract by filtration. By distilling off the solvent from the extract, 71 g (yield 85%) of 2,5-pyrazinedicarboxylic acid (3) was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dimethylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; IHI Corporation; Waseda University; Sato, Yutaka; Kanomata, Norihiro; Yuchi, Takeshi; (19 pag.)JP2018/140981; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem