486460-20-2, The chemical industry reduces the impact on the environment during synthesis 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, I believe this compound will play a more active role in future production and life.
3-(Trifluoromethyl)-l,2,4-triazolo[4,3-a] pyrazine (540 mg, 2.87 mmol, from Step A)was hydrogenated under atmospheric hydrogen with 10% Pd/C (200 mg) as a catalyst in ethanol (10 mL)at ambient temperature for 18 h. Filtration through Celite followed by concentration gave a dark coloredoil. Dichloromethane was added to the above oil and the insoluble black precipitate was filtered off.Concentration of the filtrate gave the title compound as an oil.’H NMR (500 MHz, CDC13) 5 2.21 (br, 1H), 3.29 (t, 2H, J = 5.5 Hz), 4.09 (t, 2H, J = 5.5 Hz), 4.24 (s,2H); LC-MS 193 (M+l).
The chemical industry reduces the impact on the environment during synthesis 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem