4858-85-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4858-85-9 as follows.
2,3-Dichloropyrazine A-1 (15 g; 100.68 mmol) and hydrazine hydrate 65 % (15.509 ml; 201.37 mmol) are dissolved in 45 ml ethanol and stirred for 1 h at 80 C. While cooling down, a precipitate is formed. It is slurred up with a small amount of water and filtered off. It is washed with water and then dried to afford the product. Yield: 93% (13.6 g; 94.07mmol) HPLC-MS: (M+H)+ = 145/147; tRet = 0.34 min; method FECB5
According to the analysis of related databases, 2,3-Dichloropyrazine, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; WO2015/67770; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem