Introduction of a new synthetic route about 957344-74-0

The chemical industry reduces the impact on the environment during synthesis 5,8-Dibromoimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 957344-74-0

Step 3 4-(5-Bromoimidazo[l,2-a]pyrazin-8-ylamino)-N-(2-diethylaminoethyl) benzene sulfonamide[00262] A mixture of 5,8-dibromoimidazo[l,2-a]pyrazine (1.Og, 3 6mmol), 4-amino-N-(2- diethylaminoethyl)benzenesulfonamide (109mg, 0 4mmol), Pd2(dba)3 (7mg, 0.007mmol), Xantphos(8.4mg, 0.015mmol) and Cs2CO3 (167mg, 0 52mmol) in dioxane is heated at 850C under nitrogen for 18 hours The reaction is cooled to room temperature then evaporated to dryness The residue is chromatographed on silica gel, elutmg with DCM then 98 2 DCM NH3 (7N m MeOH), and the fractions containing the title compound are combined and evaporated to afford a dark oil This oil contains an impurity, but is used in the subsequent step without further purification

The chemical industry reduces the impact on the environment during synthesis 5,8-Dibromoimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem